Saffron Extract Shows Promise for Mood and Self-Esteem in Menopause

The 12-week study, led by Dr. Adrian Lopresti, observed 86 women aged 50–70. Participants receiving the extract reported a 50.7% reduction in low mood scores, compared to 31.9% in the placebo group. Nearly half of those taking the supplement met the responder criteria for the Depression, Anxiety and Stress Scale, roughly double the success rate seen in the control group. Beyond mood, the study noted a 10% improvement in self-esteem scores among the treatment group, assessed via the Rosenberg Self-Esteem Scale.

Researchers point to the extract’s concentration of Lepticrosalides—a complex of safranal and crocins—as a key factor in its efficacy. The study suggests that by modulating neurotransmitters like serotonin and dopamine, and reducing systemic inflammation, the extract may address both the psychological and physiological roots of menopausal distress. According to Pharmactive Biotech Products, the findings support a holistic approach to healthy aging, positioning the supplement as a viable tool for women navigating the hormonal and emotional shifts of menopause.